The main objective of HARMONISE is to provide an End-to-End interoperable & hierarchical solution to support, encourage and scale up the transformation of traditional districts to Positive Energy Districts (PEDs) through optimal design, management, and integration in an interoperable, scalable, and replicable manner, following a user-centered approach, from the technology, business operation and social engagement perspectives, empowering the transition towards the European Super Grid . The consortium aims to offer a hierarchical approach, integrating, fog-enabled devices, co-simulation modules, open-standard interfaces, APIs, and open-standard System Structure and Parameterization (SSP) that will enable the connection with other tools and established networks. Additionally, a user engagement app will be presented to support the development of active business models, energy awareness and incentivize stakeholder involvement and entrepreneurship. Furthermore, the consortium plans to introduce a transactive energy approach via a blockchain-based network that allows dynamic and secure smart contracts and energy exchange. HARMONISE will support the management and expansion of multisectoral PEDs, including electricity and heating networks, RES integration, mobility schemes, and energy storage problems by unifying energy transactions. HARMONISE will be demonstrated in 4 physical pilots and 1 digital pilot case that will incorporate all the other cases to a super nova Grid.