Genetics & Genomics of Cancer and Chronic Diseases

Laboratory Details

Laboratory Title: Genetics & Genomics of Cancer and Chronic Diseases

Faculty: Professor of Genetics Ioanna Maroulakou

School: School of Health Sciences

Email: imaroula@mbg.duth.gr

Telephone: 25510 30666/6980818352

Official Gazette of Establishment:

Introduction - Presentation

Field of Research

The Laboratory serves the educational, research, and developmental needs of the Department. Specifically, it supports the academic fields of Genetics, Cancer Genomics, Genetics of Acquired Diseases, and Translational Medicine, while simultaneously conducting research activities and providing specialized services in the fields of Cancer Genetics and Genomics and Chronic Diseases. The main research areas of the Laboratory include: * Genetically engineered animal models of human diseases. * Development and application of novel genetically engineered mouse models, as well as *ex vivo* organoid and tissue culture systems. * Mechanisms underlying cancer initiation, development, and progression. * Tumor dormancy and mechanisms of cancer recurrence. * Effects of anticancer drugs on the brain and behavior. * Identification and evaluation of biomarkers in the early and progressive stages of Alzheimer's disease. * Investigation of the molecular, genetic, and epigenetic mechanisms involved in cancer and Alzheimer's disease. Through these activities, the Laboratory makes a significant contribution to the advancement of basic, translational, and clinical research, while also supporting the education and training of undergraduate and postgraduate students in contemporary and innovative fields of Health Sciences.

Laboratory Members

Name	Position/Capacity	Email	Telephone
Ioanna Maroulakou	Professor of Genetics /Director of the laboratory "of Genetics & Genomics of Cancer and Chronic Diseases"	imaroula@mbg.duth.gr	25520 30666/+30 6980818352
5	Undergraduate Thesis Students:
1	Ph.D student
1	Msc. Thesis student

Featured Research Programs

Programme Title	Duration	Funding
Programme for Infrastructure: EATRIS-GR	2019–2022	The infrastructure was funded through the General Secretariat for Research and Technology (GSRT) Infrastructure Programme
Programme for Infrastructure: Infrafrontier/Phenotypos-GR	2017–2020	The infrastructure was funded through the General Secretariat for Research and Technology (GSRT) Infrastructure Programme
InTechThrace: Integrated Technologies in Biomedical Research – Multilevel Biomarker Analysis in Thrace	2020–2023	The infrastructure was funded through the General Secretariat for Research and Technology (GSRT)

Featured Publications

Chronological Order	APP	doi
Talli I, Dovrolis N, Oulas A, Stavrakaki S, Makedou K, Spyrou GM, Maroulakou I. Novel clinical, molecular and bioinformatics insights into the genetic background of autism. Hum Genomics. 2022 Sep 18;16(1):39.
Dovrolis N, Kolios G, Spyrou G, Maroulakou I. Laying in silico pipelines for drug repositioning: a paradigm in ensemble analysis for neurodegenerative diseases. Drug Discov Today. 2017 May;22(5):805-813.
Maroulakou IG, Oemler W, Naber SP, Tsichlis PN. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in Mouse Mammary Tumor Virus (MMTV)-ErbB2/Neu and PolyomaMiddle T mice. Cancer Res 2007; 67(1): 167-77