Laboratory of Biology (Medical Biology Laboratory)
The Laboratory of Biology / Medical Biology Laboratory at the Department of Medicine, Democritus University of Thrace, studies the molecular mechanisms of viruses and their interactions with host cells and organisms. Its work combines research, education, and scientific services, with emphasis on virology, virus-host interactions, molecular diagnostics, and public-health relevant pathogens.
Laboratory Details
Laboratory Title: Laboratory of Biology (Medical Biology Laboratory)
Faculty: Faculty of Health Sciences
School: Medicine
Email: ioakarak@med.duth.gr
Telephone: +30 25510 30581
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Introduction - Presentation
The Laboratory of Biology / Medical Biology Laboratory at the Department of Medicine, Democritus University of Thrace, studies the molecular mechanisms of viruses and their interactions with host cells and organisms. Its work combines research, education, and scientific services, with emphasis on virology, virus-host interactions, molecular diagnostics, and public-health relevant pathogens.
Field of Research
Molecular virology; virus-host interactions; genomic and metagenomic studies of viruses and vector-borne pathogens; molecular diagnostics; PCR/Real-Time PCR services.
Laboratory Members
| Name | Position/Capacity | Telephone | |
|---|---|---|---|
| Ioannis Karakasiliotis, PhD | Director | ioakarak@med.duth.gr | +30 25510 30581 |
| Stavroula Veletza, PhD | Faculty Member | sveletza@med.duth.gr | |
| Elisavet Gatzidou, PhD | Special Teaching Staff | egkatzid@med.duth.gr | |
| Nikolas Dovrolis, PhD | Postdoctoral Researcher | ndovroli@med.duth.gr | |
| Marios Dimitriou, MSc | PhD Candidate | ||
| Anastasios Vasileiadis, MSc | PhD Candidate | anvasilei@med.duth.gr | |
| Sofia Markaki, Msc | PhD Candidate | smarkaki@med.duth.gr |
Featured Research Programs
| Programme Title | Duration | Funding |
|---|---|---|
| INSEQT: vectors and vector-borne diseases / insect metabarcoding | 2018–2022 | EYDE-ETAK “RESEARCH – CREATE – INNOVATE”; 699,923.20 EUR from 1,000,000 EUR total grant |
| Global changes in post-transcriptional regulators during West Nile virus replication | 2018–2020 | Fondation Santé Research Grant; 50,000 EUR |
| Metagenomic mapping of pollen and viruses in the apiaries of Thrace | 2021–2022 | Ministry of Agricultural Development and Food; 23,744 EUR |
Featured Publications
| Chronological Order | APP | doi |
|---|---|---|
| Bampali, M., Kouvela, A., Kesesidis, N., Kassela, K., Dovrolis, N., & Karakasiliotis, I. (2024). West Nile Virus Subgenomic RNAs Modulate Gene Expression in a Neuronal Cell Line. Viruses, 16(5), 812. | https://doi.org/10.3390/v16050812 | |
| Gkekas I, Katsamakas S, Mylonas S, Fotopoulou T, Magoulas GΕ, Tenchiu AC, Dimitriou M, Axenopoulos A, Rossopoulou N, Kostova S, Wanker EE, Katsila T, Papahatjis D, Gorgoulis VG, Koufaki M, Karakasiliotis I, Calogeropoulou T, Daras P, Petrakis S. AI Promoted Virtual Screening, Structure-Based Hit Optimization, and Synthesis of Novel COVID-19 S-RBD Domain Inhibitors. J Chem Inf Model. 2024 | https://doi.org/10.1021/acs.jcim.4c01110 | |
| Konstantinidis K, Dovrolis N, Kouvela A, Kassela K, Rosa Freitas MG, Nearchou A, de Courcy Williams M, Veletza S, Karakasiliotis I. Defining virus- carrier networks that shape the composition of the mosquito core virome of a local ecosystem. Virus Evol. 2022 Apr 16;8(1):veac036. doi: 10.1093/ve/veac036 | https://doi.org/10.1093/ve/veac036 |
Infrastructure and Equipment
Patents
| Patent Title | Patent Number | Publication Date | Inventor/Company | Summary | URL |
|---|---|---|---|---|---|
| Compounds with activity against SARS-CoV-2 | PCT/EP2024/060458; WO2024218171A1 | 2024-10-24 | Applicants: National Hellenic Research Foundation; Centre for Research and Technology Hellas; Democritus University of Thrace; National and Kapodistrian University of Athens; Daras Petros; Axenopoulos Apostolos; Mylonas Stylianos; Katsamakas Sotirios; Stamatopoulos Konstantinos; Petrakis Spyridon; Karakasiliotis Ioannis. Inventors: Daras P.; Axenopoulos A.; Mylonas S.; Katsamakas S.; Stamatopoulos K.; Petrakis S.; Karakasiliotis I.; Calogeropoulou T.; Koufaki M.; Papahatjis D.; Gorgoulis V. | Patent application for compounds with activity against SARS-CoV-2. International application: PCT/EP2024/060458; publication number: WO2024218171A1; publication date: 24 October 2024; priority date: 18 April 2023. |
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